Born in St. Johns, Michigan, he studied journalism at the University of Michigan. His first job was at the Peoria Journal in Peoria, Illinois. In 1917 he moved to Detroit, where he went to work for the Cadillac Motor Company as a copywriter. After his marriage he moved to Indianapolis, Indiana, where he worked for an advertising agency from 1923 - 1930. In 1935, he created his own agency - now known as Leo Burnett Worldwide. During the 1950s he moved his agency to Chicago.
He was inducted to the Copywriters Hall of Fame in 1961, and retired in 1967. Leo Burnett was frequently asked by young people about how he got involved in advertising, and his answer was invariably: "I didn't just happen to get into advertising, advertising got into me." With a career spanning 56 years, Burnett's achievements are innumerable.